POLYNUCLEOTIDES (PN) AT A GLANCE
Polynucleotides are regenerative injectable treatments designed to support tissue repair, collagen production, skin quality and cellular recovery. Unlike treatments focused primarily on hydration or volume, they support the skin's natural repair processes and improve tissue resilience over time.
Commonly Used For
- ✔Under-eye rejuvenation
- ✔Menopause skin change
- ✔Crepey skin
- ✔Skin thinning
- ✔Skin quality decline
- ✔Post-inflammatory recovery
- ✔Healthy ageing
- ✔Tissue regeneration
What Are Polynucleotides?
Polynucleotides (PDRN / PN / PNA) are DNA fragments derived from natural sources that help repair the skin at a cellular level. They work by stimulating fibroblasts, supporting collagen production, improving elasticity, encouraging tissue repair and helping regulate inflammation. Rather than simply hydrating the skin or replacing lost volume, Polynucleotides focus on supporting healthier skin behaviour through regeneration and recovery. This makes them particularly valuable for fragile, thinning or stressed skin where resilience has declined. At ULANDA, Polynucleotides are frequently incorporated into programmes addressing menopause skin change, under-eye ageing, skin thinning, inflammation-related concerns and healthy ageing.
Frequently Addressed
- •Thickens and strengthens the skin
- •Improves elasticity and firmness
- •Supports collagen production
- •Improves hydration
- •Reduces inflammation and redness
- •Supports skin recovery
- •Excellent for under-eye rejuvenation without filler
- •Supports long-term skin quality
Why Women Choose Polynucleotides
Biological repair focus
Designed to support skin repair mechanisms rather than surface-level correction.
Thinning and fragility support
Frequently selected when skin becomes thinner, crepey or less resilient.
Under-eye suitability
Commonly used for creasing, pigmentation and tissue fragility around the eye area.
Menopause skin support
Often integrated into programmes where collagen decline and fragility are more visible.
Regenerative strategy
Supports strengthening and recovery rather than masking skin changes.
Why Polynucleotides Are Different
Many treatments focus on
- •Hydration
- •Volume restoration
- •Surface correction
Polynucleotides focus on
- •Repair
- •Recovery
- •Regeneration
- •Resilience
Best For
- ✔Menopause skin thinning
- ✔Fine lines
- ✔Under-eye crepiness
- ✔Under-eye hollowness
- ✔Acne scarring
- ✔Dull or fragile skin
- ✔Slow healing skin
- ✔Inflammatory skin conditions
- ✔Skin quality decline
- ✔Healthy ageing support
May Be Appropriate For
This treatment may support the following conditions.
Crepey skin
Supports tissue quality and elasticity.
Crepey under-eye skin
Frequently used in under-eye rejuvenation plans.
Dark circles
May support skin quality where tissue fragility contributes.
Dull dehydrated skin
Supports healthier regenerative skin behaviour.
Enlarged pores
Can be part of wider skin quality programmes.
Menopause skin decline
Supports resilience during collagen and elasticity changes.
Neck crepiness
Used to support tissue quality and hydration.
Post-inflammatory hyperpigmentation
May be included in recovery-focused programmes.
Skin laxity
Supports structural skin resilience over time.
Tear trough concerns
Alternative regenerative support where filler is not the primary goal.
Texture decline
Improves smoothness and quality through regeneration.
Under-eye pigmentation
May support tissue quality around under-eye discolouration.
Uneven texture
Supports long-term texture improvement.
Commonly Considered For
Under-Eye Concerns
Frequently used around the eye area where thinning, creasing, pigmentation and tissue fragility contribute to a tired appearance.
Explore Under-Eye Concerns →Menopause Skin Change
Hormonal transition can accelerate collagen loss, reduce skin thickness and compromise elasticity.
Explore Menopause & Hormonal Skin Change →Crepey Skin & Skin Thinning
Supports regenerative processes involved in maintaining healthier skin structure.
Healthy Ageing & Skin Quality
Often used in prevention-focused strategies where the goal is stronger, healthier and more resilient skin.
Explore Facial Balance & Vitality →Skin Recovery & Repair
Frequently incorporated into programmes supporting recovery after inflammation, barrier compromise or prolonged skin stress.
Explore Dehydration, Dullness & Skin Recovery →Post-Inflammatory Skin Change
Where previous inflammation has contributed to textural change or reduced skin quality.
Explore Pigmentation, Melasma & Uneven Tone →The ULANDA Clinical System™
Treatments at ULANDA are delivered within the ULANDA Clinical System™, our diagnostic-led model of care that places clinical understanding before treatment selection.
Before treatment proceeds, your clinician completes a Focused Clinical Assessment to confirm that Polynucleotides remains appropriate for your skin, your goals and your current clinical presentation.
Where underlying factors such as barrier dysfunction, inflammation, hormonal change or broader skin health concerns are identified, your clinician may recommend integrating this treatment into a more comprehensive treatment plan or Signature Programme to support safer, more predictable and longer-lasting outcomes.
Understanding Before Treatment™ guides every recommendation we make.
Results Timeline
1–2 Weeks
Skin often feels calmer, healthier and more hydrated.
2–6 Weeks
Improvement in skin quality, tissue resilience and elasticity becomes increasingly noticeable.
6–12 Weeks
Progressive collagen support and regenerative improvements continue to develop.
Long-Term Maintenance
Periodic treatments may help support ongoing tissue quality, resilience and healthy ageing.
Perfect Treatment Pairings
Polynucleotides are frequently integrated with complementary regenerative and skin-quality treatments.
PRP
Supporting natural healing and collagen activity.
Regeneration and growth-factor support.
Learn More →Microneedling
Supporting collagen stimulation and texture improvement.
Collagen induction plus regenerative repair.
Learn More →Chemical Peels
Supporting skin renewal and clarity.
Surface refinement alongside tissue recovery.
Learn More →Skin Boosters
Profhilo and Jalupro to support hydration and elasticity.
Regeneration plus hydration strategy.
Learn More →Anti-Wrinkle Treatments
Supporting facial harmony and healthy ageing.
Expression and skin-quality management together.
Learn More →Treats Conditions
This treatment is effective for the following conditions.
Why These Changes Happen
Read the clinical context behind this treatment approach.
Menopause and Under-Eye Ageing: Why Creasing and Hollowness Accelerate
Discover why menopause accelerates under-eye creasing and hollowness. Nurse-led clinical insight from ULANDA in Ware, Hertfordshire.
Menopause and Collagen Loss: Why Structural Ageing Accelerates in Midlife
Understand why collagen loss accelerates during menopause and how structural ageing changes in midlife. Nurse-led clinical insight from ULANDA, Ware Hertfordshire.
Crepey Skin and Elasticity Loss: What It Means and How to Treat It Safely
Understand why crepey skin develops and how elasticity loss can be treated safely. Nurse-led clinical guidance from ULANDA in Ware, Hertfordshire.
Under-Eye Ageing in Menopause: Why Hollowness and Creasing Accelerate
Discover why under-eye hollowness and creasing accelerate during menopause. Nurse-led clinical insight from ULANDA in Ware, Hertfordshire.
Oestrogen, Collagen and Elasticity: Why Skin Changes Rapidly in Midlife
Learn how declining oestrogen affects collagen, elastin and skin elasticity in midlife. Nurse-led clinical insight from ULANDA in Ware, Hertfordshire.
Menopause and Skin Biology: How Hormonal Shifts Change Skin Behaviour
Discover how menopause affects collagen, elastin and barrier stability. Nurse-led clinical insight from ULANDA in Ware, Hertfordshire.
Enlarged Pores: Why They Become More Visible Over Time
My pores didn't used to look like this. Understand why pores become more visible over time and what this often signals about skin architecture.
Acne Scarring Explained: Why Texture Changes Remain After Breakouts
My acne has gone. Why doesn't my skin look the same? Understand why textural change can remain after breakouts and how skin architecture is affected.
The ULANDA Clinical System™
Treatments at ULANDA are delivered within the ULANDA Clinical System™, our diagnostic-led model of care that places clinical understanding before treatment selection.
Before treatment proceeds, your clinician completes a Focused Clinical Assessment to confirm that Polynucleotides remains appropriate for your skin, your goals and your current clinical presentation.
Where underlying factors such as barrier dysfunction, inflammation, hormonal change or broader skin health concerns are identified, your clinician may recommend integrating this treatment into a more comprehensive treatment plan or Signature Programme to support safer, more predictable and longer-lasting outcomes.
Understanding Before Treatment™ guides every recommendation we make.
Repair at the Cellular Level
Book your Polynucleotides consultation at ULANDA and discover how regenerative skin repair can support stronger, healthier and more resilient skin.
Includes a Focused Clinical Assessment to confirm treatment suitability before treatment proceeds.
Not sure where to begin? Explore the Advanced Skin Health Consultation →
Questions Women Commonly Ask About Polynucleotides
Polynucleotides are regenerative injectable treatments that support tissue repair, collagen production and skin recovery.
They support biological repair processes by stimulating fibroblasts, encouraging collagen production and helping regulate inflammatory activity.
No. Profhilo primarily focuses on hydration and elasticity. Polynucleotides are more focused on tissue repair, regeneration and cellular recovery.
Skin boosters are primarily hydration-focused. Polynucleotides place greater emphasis on regeneration and tissue repair.
Yes. They are among the most commonly used regenerative options for under-eye tissue quality concerns.
Yes. They are commonly used where menopause-related decline in collagen, elasticity and resilience is present.
Most protocols involve a course of two to four sessions, followed by maintenance based on individual response and goals.
Yes. The combination is common because microneedling supports collagen stimulation while Polynucleotides support regeneration and recovery.
THE ULANDA CONNECTION — HOW POLYNUCLEOTIDES SUPPORT SKIN REPAIR & HEALTHY AGEING
At ULANDA, Polynucleotides are not viewed simply as another injectable treatment.
They are incorporated into broader programmes designed to support skin repair, menopause skin change, under-eye rejuvenation, tissue resilience and healthy ageing.
The goal is not simply hydration.
The goal is helping the skin recover, strengthen and behave more like healthy skin again.
Protocol: AI skin analysis is used to identify thinning and repair-priority zones. Typical course is 2–4 sessions and may be combined with Microneedling, PRP or Skin Boosters depending on treatment goals.
Look Like Yourself. Feel Like Yourself. Understanding Before Treatment.